Weinreich, Michael, Ph.D.

Dr. Weinreich received his Ph.D. in biochemistry from the University of Wisconsin–Madison in 1993. He then was a postdoctoral fellow in the laboratory of Bruce Stillman, director of the Cold Spring Harbor Laboratory, New York, from 1993 to 2000. Dr. Weinreich joined VARI as a Scientific Investigator in March 2000 and was promoted to Senior Scientific Investigator in 2008.

Harkins, V., C. Gabrielse, L. Haste, and M. Weinreich. 2009. Budding yeast Dbf4 sequences required for Cdc7 kinase activation and identification of a functional relationship between the Dbf4 and Rev1 BRCT domains. Genetics 183(4): 1269–1282.  PubMed   Article  

Miller, C.T., C. Gabrielse, Y.C. Chen, and M. Weinreich. 2009. Cdc7p-Dbf4p regulates mitotic exit by inhibiting polo kinase. PLoS Genet. 5(5): e1000498.  PubMed   Article  

Shor, E., C.L. Warren, J. Tietjen, Z. Hou, U. Müller, I. Alborelli, F.H. Gohard, A.I. Yemm, L. Borisov, J.R. Broach, M. Weinreich, C.A. Nieduszynski, A.Z. Ansari, and C.A. Fox. 2009. The origin recognition complex interacts with a subset of metabolic genes tightly linked to origins of replication. PLoS Genet. 5(12): e1000755.  PubMed   Article  

Bonte, D., C. Lindvall, H. Liu, K. Dykema, K. Furge, and M. Weinreich. 2008. Cdc7-Dbf4 kinase overexpression in multiple cancers and tumor cell lines is correlated with p53 inactivation. Neoplasia 10(9): 920–931.  PubMed   Article  

Chang, F., J.F. Theis, J. Miller, C.A. Nieduszynski, C.S. Newlon, and M. Weinreich. 2008. Analysis of chromosome III replicators reveals an unusual structure for the ARS318 silencer origin and a conserved "WTW" sequence within the ORC binding site. Molecular and Cellular Biology 28(16): 5071-5081.  PubMed   Article  

Crampton, A., F. Chang, D.L. Pappas, Jr., R.L. Frisch, and M. Weinreich. 2008. An ARS element inhibits DNA replication through a SIR2-dependent mechanism. Mol. Cell 30(2): 156-166.  PubMed   Article  

Gabrielse, C., C.T. Miller, K.H. McConnell, A. DeWard, C.A. Fox, and M. Weinreich. 2006. A Dbf4p BRCA1 C-terminal-like domain required for the response to replication fork arrest in budding yeast. Genetics 173(2): 541-555.  PubMed   Article  

Bose, M.E., K.H. McConnell, K.A. Gardner-Aukema, U. Müller, M. Weinreich, J.L. Keck, and C.A. Fox. 2004. The origin recognition complex and Sir4 protein recruit Sir1p to yeast silent chromatin through independent interactions requiring a common Sir1p domain. Molecular and Cellular Biology 24(2): 774-786.  PubMed   Article  

Pappas, D.L., Jr., R. Frisch, and M. Weinreich. 2004 . The NAD(+)-dependent Sir2p histone deacetylase is a negative regulator of chromosomal DNA replication.. Genes and Development 18(7): 769-781.  PubMed   Article  

Weinreich, M., M.A. Palacios DeBeer, and C.A. Fox. 2004. The activities of eukaryotic replication origins in chromatin. Biochimica et Biophysica Acta 1677(1-3): 142-157.  PubMed   Article  

Weinreich, M., C. Liang, H.-H. Chen, and B. Stillman. 2001. Binding of cyclin-dependent kinases to ORC and Cdc6p regulates the chromosome replication cycle. Proceedings of the National Academy of Sciences U.S.A 98(20): 11211–11217.  PubMed   Article