Weinreich, Michael, Ph.D.
Senior Scientific Investigator

Phone: 616-234-5306
Fax: 616-234-53

E-Mail Lab

Weinreich, Michael, Ph.D.

Dr. Weinreich received his Ph.D. in biochemistry from the University of Wisconsin–Madison in 1993. He then was a postdoctoral fellow in the laboratory of Bruce Stillman, director of the Cold Spring Harbor Laboratory, New York, from 1993 to 2000. Dr. Weinreich joined VARI as a Scientific Investigator in March 2000 and was promoted to Senior Scientific Investigator in 2008.

Selected Publications

Bonte, D., C. Lindvall, H. Liu, K. Dykema, K. Furge, and M. Weinreich. 2008. Cdc7-Dbf4 kinase overexpression in multiple cancers and tumor cell lines is correlated with p53 inactivation. Neoplasia 10(9): 920–931.  PubMed   Article  

Chang F, Theis JF, Miller J, Nieduszynski CA, Newlon CS, Weinreich M. 2008. Analysis of chromosome III replicators reveals an unusual structure for the ARS318 silencer origin and a conserved "WTW" sequence within the ORC binding site. Molecular and Cellular Biology 28(16): 5071-5081.  PubMed   Article  

Crampton, A., F. Chang, D.L. Pappas, Jr., R.L. Frisch, and M. Weinreich. 2008. An ARS element inhibits DNA replication through a SIR2-dependent mechanism. Mol. Cell 30(2): 156-166.  PubMed   Article  

Gabrielse, C., C.T. Miller, K.H. McConnell, A. DeWard, C.A. Fox, and M. Weinreich. 2006. A Dbf4p BRCA1 C-terminal-like domain required for the response to replication fork arrest in budding yeast. Genetics 173(2): 541-555.  PubMed   Article  

Pappas, Donald L., Jr., Ryan Frisch, and Michael Weinreich. 2004 . The NAD(+)-dependent Sir2p histone deacetylase is a negative regulator of chromosomal DNA replication.. Genes and Development 18(7): 769-781.  PubMed   Article  

Weinreich, Michael, Madeline A. Palacios DeBeer, and Catherine A. Fox. 2004. The activities of eukaryotic replication origins in chromatin. Biochimica et Biophysica Acta 1677(1-3): 142-157.  PubMed   Article  

Bose, Melissa E., Kristopher H. McConnell, Kelly A. Gardner-Aukema, Ulrika Müller, Michael Weinreich, James L. Keck, and Catherine A. Fox. 2004. The origin recognition complex and Sir4 protein recruit Sir1p to yeast silent chromatin through independent interactions requiring a common Sir1p domain. Molecular and Cellular Biology 24(2): 774-786.  PubMed   Article  

Weinreich, Michael, Chun Liang, Hsu-Hsin Chen, and Bruce Stillman. 2001. Binding of cyclin-dependent kinases to ORC and Cdc6p regulates the chromosome replication cycle. Proceedings of the National Academy of Sciences U.S.A 98(20): 11211–11217.  PubMed   Article